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By building on the capabilities of our staff and creating a culture that questions and challenges the way we do things, we strive to continuously evolve. Our working culture is open, creative, friendly and collaborative and we welcome applications from dynamic and experienced team members to help us achieve our ambitions and goals.
No recruitment agencies please as we will be unable to respond to you.
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. We are expanding our research and development team at our premises just outside Cambridge UK.
We are looking for a curious, enthusiastic scientist to join our Platform Development team. Here, they will collaborate with teams across the company and contribute the development of technologies in DNA synthesis, mRNA synthesis and gene expression. This role would suit someone with previous lab work experience and is eager to apply themselves and learn new skills in a dynamic, innovative, and collaborative environment.
Responsibilities:
- Work as part of the Platform Development team
- Plan and execute projects, assess problems, and troubleshoot to ensure successful and on-time project delivery
- Work collaboratively and support the R&D functions of the Company
- Attend and participate in relevant meetings, training, and development sessions
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Keep up to date with relevant scientific and technical developments
- Establish and maintain a detailed record of all the experiments and results generated in the lab
Person Specification:
- MSc or equivalent experience in biochemistry, molecular biology, or related life science field
- Hands-on experience working in biology or chemistry labs
- Experience with lab techniques such as gel electrophoresis, PCR and DNA quantification
- Experience performing DNA/RNA extraction/precipitation
- Ability to test and troubleshoot new assays and techniques
- Excellent problem-solving skills and critical thinking
- Excellent team working and communication skills
- Ability to analyze and interpret experimental data using R, GraphPad, or Python packages
- Experience with DNA analytical techniques such as PAGE is desirable
- Experience with DNA sequence design and primer design is desirable
- Experience with DNA assembly and cloning is desirable
- Must hold the right to work in the UK
What we can offer:
Competitive salary + comprehensive benefits packageIf you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
**NO AGENCIES PLEASE**
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and gene editing platforms. We are expanding our MSAT team at our site just north of Cambridge, UK to facilitate the purification of synthetic DNA products for use in AAV, IVT mRNA processes and other therapeutic areas. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.
The role will focus on supporting the purification of synthetic DNA products. In addition, there will be opportunity for the candidate to interact with multi-disciplinary teams within the Research department and expand their laboratory skill set.
Job Responsibilities:
- Work as part of the MSAT team as a purification lab technician, working to support the purification of synthetic DNA products
- Aid in the planning, execution, and delivery of purification projects to a high standard and in accordance with project plans
- Perform the final fill and finish of synthetic DNA products
- Work collaboratively and support the Manufacturing and R&D functions of the company
- Attend and participate in relevant meetings, training, and development sessions
- Use, maintain and respect company equipment in accordance with the company’s SOPs and health & safety guidelines
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Keep up to date with relevant scientific and technical developments
- Establish and maintain a detailed record of all the experiments and results generated in the lab
- Be prepared to travel to other 4basebio sites
Person Specification:
- BSc in biochemistry, molecular biology, or related life science is desirable
- Hands-on experience working in biology or chemistry labs
- Experience in DNA and protein handling
- Experience in protein purification with AKTA systems desirable
- Experience in analytical techniques such agarose gels, nucleic acids quantification techniques
- Experience in TFF system operation is desirable
- Excellent team working and communication skills
- Must hold the right to work in the UK
What we offer:
Competitive salary + comprehensive benefits packageIf you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
**NO AGENCIES PLEASE**
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and gene editing platforms. The company is growing rapidly and is establishing a GMP gene synthesis hub at its site just north of Cambridge, UK to facilitate the scaling and optimisation of a proprietary DNA manufacturing process.
As QA Manager you will help 4basebio to achieve and maintain compliance with current Good Manufacturing Practices (cGMP). The role will manage a small team to ensure the Quality Management System (QMS) operates effectively, in a business striving to build quality into the every-day.
Job Responsibilities:
- Contribute to the implementation of key Quality elements in line with cGMP, taking the lead as needed
- Take responsibility for ongoing management of the QMS as a senior member of the QA Team. For example, supplier management, internal auditing/self-inspection, stability programs, change control, deviations, investigations, corrective actions, and risk management
- Support and host audits by customers and regulatory bodies
- Be prepared to deliver group and individual training on QMS and cGMP topics
- Maintain QMS documentation, keep accurate records and comply with company policies in accordance with cGMP regulations
- Advocate compliant and efficient application of cGMP and the Quality Management System, and foster positive collaborations within the business
- Lead the team to excellence and nurture personal and professional development
Person Specification:
- Broad experience of cGMP Quality Assurance and Quality Management Systems
- Self-motivated and diligent, with a pragmatic mindset
- Enthusiastic and experienced people manager
- Scrupulous attention to detail and investigative thinking
- Comfortable working autonomously or collaboratively and able to prioritise
- Must hold the right to work in the UK
What we offer:
Competitive salary + comprehensive benefits package
If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within six weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
**NO AGENCIES PLEASE**
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and gene editing platforms. We are expanding our R&D team at our site in Cambridge, UK, to facilitate the scaling of our proprietary DNA manufacturing process for use in AAV and IVT mRNA processes and develop nanoparticle vectors for nucleic acid delivery. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.
The role will focus on the development and optimisation of the downstream ana analytic processes in our synthetic DNA manufacturing platform. In addition, there will be opportunity for the candidate to interact with multi-disciplinary teams within the Research department and expand their laboratory skill set.
Responsibilities:
- Work as part of the purification team, to be able of generating consistent and valuable data inside the downstream process for DNA manufacturing
- Perform as a key member of the analytics department, development new analytic techniques to assess DNA and mRNA purity and record the relevant information in detailed reports
- Confidently plan, execute, and deliver projects to a high standard and in accordance with project plans
- Analyse and interpret experimental data; identify and solve experimental problems
- Work collaboratively and support the R&D functions of the company
- Attend and participate in relevant meetings, training, and development sessions
- Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Keep up to date with relevant scientific and technical developments
- Establish and maintain a detailed record of all the experiments and results generated in the lab
Person Specification:
- MSc in biochemistry, molecular biology, or related life science field
- Hands-on experience working in biology or chemistry labs
- Expertise in DNA and protein handling
- Experience in protein purification with FPLC and/or HPLC systems
- Experience in analytical techniques such agarose gels, nucleic acids quantification techniques and qPCR
- Experience performing protein QC analytical techniques such: SDS-PAGE gels, silver staining, and plate-based assays
- Experience in TFF system operation optional
- Ability to test and troubleshoot new assays and techniques
- Excellent team working and communication skills
- Must hold the right to work in the UK
What we can offer:
Competitive salary + comprehensive benefits package
If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within 6 weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and gene editing platforms. The company is growing rapidly and is establishing a GMP gene synthesis hub at its site north of Cambridge, UK to facilitate the scaling and optimisation of our proprietary DNA manufacturing process.
As a Manufacturing Scientist you will be responsible for performing functions related to production and GMP manufacturing operations. This position requires great attention to detail, ability to work in a team environment and a keen interest in optimisation of processes. You will be responsible for adhering to all QMS policies and procedures, cGMPs and safety standards.
Job Responsibilities:
- Perform all manufacturing operations including but not limited to component transfer and preparation, equipment and area preparation, media preparation, up and downstream manufacturing, and cleaning of process areas
- Support the monitoring and maintenance of the facility and direct utilities in accordance with company & regulatory guidelines
- Maintain QMS documentation, keep accurate records, follow instructions and comply with company policies
- Contribute to housekeeping tasks to support manufacturing operations including cleaning, sanitisation and sterilisation of equipment and components
- Ensure compliance with Quality policies, SOPs and Health and Safety procedures
- Support troubleshooting activities and assist with continuous improvement initiatives
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Travel to other 4basebio sites as required
Person Specification:
- Excellent interpersonal skills, organised and enthusiastic and comfortable working autonomously or in a team environment
- Bachelor of Science degree or equivalent work experience
- Experience of working in a cell manufacturing facility to standards of GMP and Good Clinical Practice desirable
- Willingness to follow GMP PPE requirements during the working shift
- Previous manufacturing experience desirable
- Excellent attention to detail
- Must hold the right to work in the UK
What we offer:
Competitive salary + comprehensive benefits package
If you are interested in joining the 4basebio team, please forward your CV to HR@4basebio.com
Due to the high number of applicants, if you do not hear back from us within 6 weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.
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