Careers
Join our team
By building on the capabilities of our employees and creating a culture that questions and challenges the way we do things, we continuously evolve both ourselves and our Company. Our working culture is open, creative, friendly and collaborative and we welcome applications from dynamic and experienced team members to help us achieve our ambitions and goals.
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is setting up a manufacturing cell with associated quality team to produce synthetic DNA and related therapeutic products at our site near Cambridge, UK.
Responsibilities:
- Deliver and maintain a quality system to complement the technical manufacturing process being developed on site
- Build and lead the quality team
- Prepare for Regulatory and Customer audits
- To undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Be prepared to travel to other 4basebio sites
Person Specification:
- Experience of working under GMP regulation
- Experience of managing quality systems in a manufacturing environment
- PhD or 5 years’ experience in Biological Sciences, Synthetic Biology, or Bio Chem engineering manufacturing
- Ability to work in a self-directed way in a small team
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
Please note we are unable to consider candidates who do not hold the right to work in the UK
To apply, send your CV and covering email to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is setting up a manufacturing cell with associated quality system to produce synthetic DNA and related therapeutic products at our site near Cambridge, UK.
Responsibilities:
- Coordinate the delivery of regulatory support files for the company’s novel DNA products
- Design and implement a quality process to complement the technical manufacturing process being developed on site
- To undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Be prepared to travel to other 4basebio sites
Person Specification:
- Experience of working under GMP regulation, ideally within advanced therapeutics
- Experience of developing quality systems in a manufacturing environment
- PhD or 5 years’ experience in Biological Sciences, Synthetic Biology, or Bio Chem engineering manufacturing
- Delivery of regulatory support packages for life sciences
- Ability to work in a self-directed way in a small team
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
Please note we are unable to consider candidates who do not hold the right to work in the UK
To apply, send your CV and covering email to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is expanding their research and development team at our offices in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process and develop non-viral nanoparticles and AAV vectors for DNA delivery. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.
Responsibilities:
- Accountable for the development and optimisation of AAV vectors for gene therapy.
- Lead AAV production and purification systems to produce research-grade AAV.
- Mechanistically understand and improve AAV production with our synthetic DNA templates.
- Perform analytical techniques on vector preparations (qPCR, ELISA, protein gels etc).
- Ensure validity and reliability of data and maintain accurate records.
- From time-to-time support additional high-priority projects to meet deadlines.
- Attend and participate in relevant meetings, training, and development sessions.
- Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines.
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested.
- Be prepared to travel to other 4basebio sites.
Person Specification:
- PhD / MSc + industry experience in relevant scientific field.
- Extensive experience in AAV production and purification using HEK293 cells.
- Hands-on experience with molecular biology, cell culture, transfection, infection, and cell-based assays.
- Proficient in Western, ELISA, flow, PCR techniques.
- Experience cloning DNA constructs in bacterial systems.
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
To apply for this role send your CV and covering letter to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is expanding their research and development team at our offices in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process and develop non-viral nanoparticles and AAV vectors for DNA delivery. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.
Job Responsibilities:
- Accountable for carrying out routine cell culture and performing transient transfections.
- Perform analytical techniques on vector preparations (qPCR, ELISA, protein gels etc).
- Perform AAV vector purification by a range of methods.
- Ensure validity and reliability of data and maintain accurate records.
- From time-to-time support additional high-priority projects to meet deadlines.
- Attend and participate in relevant meetings, training, and development sessions.
- Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines.
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested.
- Be prepared to travel to other 4basebio sites.
Person Specification:
- Minimum BSc-degree in a relevant biological discipline + industry experience with mammalian expression of AAVs.
- Experience in protein analysis techniques (SDS-PAGE, Western, ELISA) and qPCR.
- Familiarity of AAV purification is desirable.
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
To apply for this role send your CV and covering letter to HR@4basebio.com
Contact
If you are interested in joining the 4basebio team, please forward your CV to: hr@4basebio.com
*No agencies please*
