Careers
Join our team
By building on the capabilities of our employees and creating a culture that questions and challenges the way we do things, we continuously evolve both ourselves and our Company. Our working culture is open, creative, friendly and collaborative and we welcome applications from dynamic and experienced team members to help us achieve our ambitions and goals.
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. This is a disruptive technology with tremendous potential. The company is growing rapidly, and is establishing a GMP manufacturing and process development hub at our site north of Cambridge, UK to facilitate the scaling and optimisation of our proprietary DNA manufacturing process. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.
Responsibilities:
- Development of methods for identification and purity analysis of nucleic acid constructs
- Planning and executing validation of analytical methods to feedback into process development
- Actively participate and contribute to laboratory and company meetings
- Maintain an accurate and complete record of laboratory work performed
- To use and maintain company equipment in accordance to the company’s SOPs and health & safety guidelines
- To undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Be prepared to travel to other 4basebio sites
Person Specification:
- Experience in materials characterisation/ formulation and/or flow chemistry
- Masters Degree/ equivalent experience in Chemistry/ Biochemistry
- Familiarity with assay development (e.g. ELISA, SDS-PAGE gel, Western blot, HPLC analysis)
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
To apply for this role send you CV and covering letter to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is expanding their research and development team at our site in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process and develop non-viral nanoparticle and AAV vectors for DNA delivery. We are looking for a dynamic and experienced team member to help us achieve our ambitions and goals.
The primary focus of the role will be to advance our non-viral delivery platform, with a focus on the liver. In addition, there will be opportunity for the candidate to interact with multi-disciplinary teams within the Research department and expand their laboratory skill set.
Responsibilities:
- Formulation, characterisation and testing of novel nanoparticles for gene delivery in liver cell models
- Actively participate and contribute to laboratory and company meetings
- Maintain an accurate and complete record of laboratory work performed
- To use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines
- To undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Be prepared to travel to other 4basebio sites
Person Specification:
- MSc + 2 years industry experience in relevant scientific field
- Extensive cell culture experience, liver cell models is desirable
- Highly experienced in Western, ELISA, flow, PCR techniques
- Familiarity with particle sizing techniques, e.g. Zetasizer, Microscopy desirable
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
To apply for this role send your CV and covering letter to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. This is a disruptive technology with tremendous potential. The company is growing rapidly and is establishing a GMP manufacturing and process development hub at our site north of Cambridge, UK, to facilitate the scaling and optimisation of our proprietary DNA manufacturing process.
As Head of our Process Development team, you will help drive our growth in process development and manufacture optimisation in a busy and dynamic environment.
Main responsibilities:
- Lead a team of process development scientists and technicians
- Lead and manage the process development for transfer to manufacturing
- Liaise with the quality team and incorporate recommendations into process design
- Lead experimental design and data analysis of team members
- Contribute ideas and opinions to scientific discussions to aid the development of new technologies
- Actively participate and contribute to laboratory and company meetings
- Maintain an accurate and complete record of laboratory work performed
- To use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines
- To undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
- Be prepared to travel to other 4basebio sites
You will have:
- Experience leading projects and teams in process development of nucleic acid or biologics synthesis and purification
- PhD degree in Molecular Biology/ Chemistry/ Chemical Engineering/ Biochemistry
- Experience in Molecular Biology is a must
- Familiarity with lab scale nucleic acid/ protein purification, e.g. AKTA platform, crossflow filtration
- Expertise in design of experiments
What we offer:
Competitive salary + private healthcare + pension contributions + life assurance To apply for this role send you CV and covering email to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is expanding their research and development team at our offices in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process and develop non-viral nanoparticles and AAV vectors for DNA delivery. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.
Responsibilities:
- Accountable for the development and optimisation of AAV vectors for gene therapy.
- Lead AAV production and purification systems to produce research-grade AAV.
- Mechanistically understand and improve AAV production with our synthetic DNA templates.
- Perform analytical techniques on vector preparations (qPCR, ELISA, protein gels etc).
- Ensure validity and reliability of data and maintain accurate records.
- From time-to-time support additional high-priority projects to meet deadlines.
- Attend and participate in relevant meetings, training, and development sessions.
- Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines.
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested.
- Be prepared to travel to other 4basebio sites.
Person Specification:
- PhD / MSc + industry experience in relevant scientific field.
- Extensive experience in AAV production and purification using HEK293 cells.
- Hands-on experience with molecular biology, cell culture, transfection, infection, and cell-based assays.
- Proficient in Western, ELISA, flow, PCR techniques.
- Experience cloning DNA constructs in bacterial systems.
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
To apply for this role send your CV and covering letter to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is expanding their research and development team at our offices in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process and develop non-viral nanoparticles and AAV vectors for DNA delivery. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.
Job Responsibilities:
- Accountable for carrying out routine cell culture and performing transient transfections.
- Perform analytical techniques on vector preparations (qPCR, ELISA, protein gels etc).
- Perform AAV vector purification by a range of methods.
- Ensure validity and reliability of data and maintain accurate records.
- From time-to-time support additional high-priority projects to meet deadlines.
- Attend and participate in relevant meetings, training, and development sessions.
- Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines.
- Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested.
- Be prepared to travel to other 4basebio sites.
Person Specification:
- Minimum BSc-degree in a relevant biological discipline + industry experience with mammalian expression of AAVs.
- Experience in protein analysis techniques (SDS-PAGE, Western, ELISA) and qPCR.
- Familiarity of AAV purification is desirable.
What we can offer:
Competitive salary + private healthcare + pension contributions + life assurance
To apply for this role send your CV and covering letter to HR@4basebio.com
4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. This is a disruptive technology with tremendous potential. The company is growing rapidly and is establishing a GMP manufacturing and process development hub at our site north of Cambridge, UK to facilitate the scaling and optimisation of our proprietary DNA manufacturing process. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals
We are a rapidly growing and innovative gene synthesis company. We are focussed on providing high quality synthetic DNA, a highly disruptive technology, for use in gene therapies and gene vaccines. Based just north of Cambridge, we are now establishing a GMP manufacturing and process development hub to facilitate the scaling and optimisation of our proprietary DNA manufacturing process. We are looking for an enthusiastic and experienced quality engineer to join our team.
Principal Responsibilities:
- you will assist with the design and implementation of an ISO compliant quality management system (QMS)
- support the roll out of an electronic document control system
- create, maintain and develop quality system policies
- write and review SOPs for the manufacture of synthetic DNA
To be successful in this role, you will have:
- prior experience of working in a Quality Assurance role within the biotechnology, diagnostic or biopharma manufacturing sector with a strong understanding and knowledge of ISO900x and or ISO13845 and or GMP regulation
- prior experience of working with QMS
- proven experience of creating, maintaining and developing Quality System Policies
- strong knowledge and understanding of ISO and/or GMP
- experience of using an Electronic Document Management System
- proven experience of conducting internal and supplier audits
What we offer:
Competitive salary + private healthcare + pension contributions + life assurance
To apply for this role send you CV and covering email to HR@4basebio.com
Contact
If you are interested in joining the 4basebio team, please forward your CV to: hr@4basebio.com
*No agencies please*
