https://www.4basebio.com/technical-insights daily 0.75 2026-02-19 https://www.4basebio.com/technical-insights/4basebios-synthetic-dna-manufacturing-process-safe-scalable-and-gmp-ready-dna monthly 0.5 2026-03-19 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/76cff550-0bf1-41f4-bc42-7f4f125f193c/Manufacturing+whitepaper+preview Technical Insights - 4basebio’s synthetic DNA manufacturing process: Safe, scalable and GMP-ready DNA https://www.4basebio.com/technical-insights/redefining-biomanufacturing-for-personalized-cancer-vaccines-a-synthetic-dna-approach-for-speed-scale-and-flexibility monthly 0.5 2026-03-19 https://www.4basebio.com/technical-insights/opdna-vs-plasmid-dna-a-technical-evaluation-of-ivt-mrna-manufacture monthly 0.5 2026-02-27 https://www.4basebio.com/technical-insights/accelerating-mrna-therapeutics-with-opdna-faster-cleaner-and-more-efficient-dna-synthesis monthly 0.5 2026-03-19 https://www.4basebio.com/technical-insights/category/Whitepaper monthly 0.5 https://www.4basebio.com/technical-insights/category/Technical+note monthly 0.5 https://www.4basebio.com/technical-insights/category/TECHNOTE monthly 0.5 https://www.4basebio.com/blog daily 0.75 2026-04-01 https://www.4basebio.com/blog/template-generation-feature monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/f123e6ee-f0ae-428c-8e2a-b56bcfa38646/4basebio+process+workflow Blog - Q&A Feature: How 4basebio’s master template generation step shapes next-generation DNA - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/c1f124a8-340a-488d-a857-67706e9c0b2c/Tej+2+1.jpg Blog - Q&A Feature: How 4basebio’s master template generation step shapes next-generation DNA - Tejaswini Mahadeva Tejaswini is a molecular bio scientist with expertise in synthetic DNA technologies, gene expression systems, and molecular biotechnology. She currently serves as the Template Generation Team Lead at 4basebio, where she leads the development and optimization of template generation processes that underpin the company’s synthetic DNA production platform for gene therapy and vaccine development. Alongside her leadership responsibilities, she contributes to research and development initiatives exploring next-generation DNA modalities and nucleic acid technologies. Her scientific background spans synthetic biology, molecular biology, protein engineering and purification, gene editing, and structural biology, reflecting a multidisciplinary approach to advancing biotechnology and nucleic acid-based therapeutics. https://www.4basebio.com/blog/the-switch-to-cell-free-dna-streamlining-advanced-therapy-manufacturing monthly 0.5 2026-04-01 https://www.4basebio.com/blog/why-polya-stability-matters-for-mrna-therapeutic-development monthly 0.5 2026-04-01 https://www.4basebio.com/blog/celebrating-60-years-of-aav-from-discovery-to-the-future-of-gene-therapy monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/98909c45-8a57-4eef-a72e-d8cbae7c9a83/Timeline+since+discovery+of+AAV+in+1965 Blog - Celebrating 60 Years of AAV: From Discovery to the Future of Gene Therapy - Figure 1: Major Historical milestones in AAV research and development from the discovery of AAV in 1965 up until 2025 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/64b26355-fe5a-45f1-9ac2-645c54a7177d/AAV+blog+graph.png Blog - Celebrating 60 Years of AAV: From Discovery to the Future of Gene Therapy - Make it stand out Figure 2: Number of gene therapy trials that utilize AAV, since 1995 up until 2024. Reference: (Suarez-Amaran et al., 2025) https://www.4basebio.com/blog/backbone-free-synthetic-dna-supports-safer-and-more-compliant-aav-production monthly 0.5 2026-04-01 https://www.4basebio.com/blog/leveraging-synthetic-ssdna-and-dsdna-donor-templates-for-crispr-mediated-gene-editing monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/6c67dec8-2da4-420b-95fd-16192e37a03c/ILLO-4bb_oeDNA.png Blog - Leveraging synthetic ssDNA and dsDNA donor templates for CRISPR-mediated gene editing - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/f32fe92e-200a-4943-a57b-3a6487a79544/ILLO-4bb_ssDNA.png Blog - Leveraging synthetic ssDNA and dsDNA donor templates for CRISPR-mediated gene editing - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.4basebio.com/blog/why-relying-on-plasmids-is-slowing-down-your-innovation-and-what-to-do-about-it monthly 0.5 2026-04-01 https://www.4basebio.com/blog/harnessing-synthetic-dna-for-more-efficient-and-safer-aav-manufacturingnbspnbsp monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/d561d450-5d09-44ca-b761-cec9e952d871/ILLO-4bb_hpDNA.png Blog - Harnessing synthetic DNA for more efficient and safer AAV manufacturing   - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.4basebio.com/blog/a-day-in-the-life-meet-the-msat-scientists-behind-4basebios-synthetic-dna-innovation monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/3e5029fb-ec14-42f8-8916-2eb9db22b67b/IMG_mRNA-Vaccines.jpg Blog - A day in the life: Meet the MSAT scientists behind 4basebio's synthetic DNA innovation   At 4basebio, our Manufacturing Sciences & Technology (MSAT) team is at the heart of transforming synthetic DNA innovation into tangible solutions. They sit at a critical junction, between research and large-scale production, ensuring that the synthetic DNA we develop for applications such as mRNA therapies, vaccines, and gene therapies is not only high-quality, but also scalable and timely.  But what does life really look like inside MSAT? We spent a day getting to know four team members, Surabhi, Thomas, Jessie and Deborah. Allowing us to uncover what drives them, what challenges they face, and what makes their work so meaningful. Each of them brings a unique perspective to the team and a shared passion for scientific problem-solving.  https://www.4basebio.com/blog/how-is-4basebios-synthetic-dna-made monthly 0.5 2026-04-01 https://www.4basebio.com/blog/no-bacteria-no-bottlenecks-the-future-of-dna-ivt-templates-is-synthetic monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/d296f71d-2d76-41cb-b686-3b1a78c92861/ILLO-4bb-opDNA.png Blog - No bacteria, no bottlenecks: The future of DNA IVT templates is synthetic - 4Basebio’s opDNA® is a partially opened, linear, double-stranded DNA template, that has been specifically designed as an IVT template. Each molecule features a hairpin at the 5’ end, with an opposite open 3’ end, allowing it to be fed directly into the IVT reaction without a linearisation or de-ending step. https://www.4basebio.com/blog/how-enzymatically-produced-synthetic-dna-is-accelerating-the-future-of-next-gen-therapies monthly 0.5 2026-04-01 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/f79cfa95-9e07-4b7a-ae2b-77840185d38e/Amy.jpg Blog - How enzymatically produced synthetic DNA is accelerating the future of next-gen therapies - “Our mission is to accelerate the development of next generation therapies by delivering high-performance synthetic DNA with significantly shorter lead times and performance benefits as compared to traditional plasmid-based methods.” Amy Walker COO https://www.4basebio.com/brochures daily 0.75 2026-04-02 https://www.4basebio.com/brochures/opdna-template-technology-for-mrna-synthesis monthly 0.5 2026-04-02 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/7594e456-bc6e-4aaa-9c4f-52b59942adeb/BLOGSWHITEPAPERSARTICLESCASESTUDIES.jpg Brochures & Flyers - opDNA® Template Technology for mRNA Synthesis | Flyer - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.4basebio.com/brochures/the-switch-to-cell-free-dna monthly 0.5 2026-03-09 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/15ddd85d-3077-493e-ae92-321f641c96db/4B26-04+Cell-free+DNA+infographic_thumbnail.png Brochures & Flyers - The Switch to Cell-Free DNA | Strategic and regulatory considerations Gene and cell therapy manufacturers are increasingly transitioning from plasmid DNA to cell-free DNA as a critical starting material. The benefits are clear: faster production, improved safety profiles, and greater flexibility for complex sequences. The challenge? Demonstrating regulatory comparability between your old and new processes. This quick reference guide outlines the key advantages of cell-free DNA, explains what "comparability" means to regulatory agencies, and provides a practical roadmap for your transition—from risk assessment and analytical testing to regulatory submission strategies. https://www.4basebio.com/brochures/gmp-grade-synthetic-dna-services monthly 0.5 2026-01-28 https://www.4basebio.com/brochures/application-specific-dna-constructs monthly 0.5 2025-06-24 https://www.4basebio.com/brochures/category/BROCHURE monthly 0.5 https://www.4basebio.com/brochures/category/Flyer monthly 0.5 https://www.4basebio.com/articles daily 0.75 2025-09-11 https://www.4basebio.com/articles/transformative-advances-in-viral-vector-manufacturing-unlocking-commercial-scalability-consistency-and-cost-effectiveness monthly 0.5 2025-09-11 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/e3a2a8a6-1a85-4c0b-a140-238f42ca8320/Helix+Illustration+in+light+blue+and+pink Articles - Transformative advances in viral vector manufacturing: Unlocking commercial scalability, consistency, and cost-effectiveness - Make it stand out Image credit: Pharma’s Almanac https://www.4basebio.com/articles/update-title-inside-precision-medicine-asked-answered-feature monthly 0.5 2025-08-06 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/1750059729608-9MAMDHCMS13J1S34K7V4/blog+thumbnail+blue2cyan.jpg Articles - The dawn of personalized DNA vaccines: Asked & answered feature - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.4basebio.com/articles/high-quality-mrna-produced-with-synthetic-opdna-templates-collaboration-with-vernal-biosciences monthly 0.5 2025-09-11 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/1749568027647-YLUBQ9774NMGGSELJ3TS/News+%281%29.png Articles - 4basebio's synthetic DNA vs plasmid DNA for mRNA manufacturing: evaluation by Vernal Biosciences - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.4basebio.com/articles/synthetic-dna-breaking-the-bottleneck-in-genetic-medicine-manufacturing monthly 0.5 2025-08-05 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/1747913967520-F9Y9YALEMLLWPTIIX1H6/hp-banner%2B1.jpg Articles - Synthetic DNA: Breaking the bottleneck in genetic medicine manufacturing - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.4basebio.com/articles/article-1 monthly 0.5 2025-06-19 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/1747913967520-F9Y9YALEMLLWPTIIX1H6/hp-banner%2B1.jpg Articles - What makes synthetic DNA the better choice for gene therapy development? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.4basebio.com/articles/category/PRESS+RELEASE monthly 0.5 https://www.4basebio.com/articles/category/NEWS monthly 0.5 https://www.4basebio.com/news daily 0.75 2026-03-31 https://www.4basebio.com/news/4bb-announces-lease-of-innovation-hub-and-manufacturing-facility monthly 0.5 2026-04-01 https://www.4basebio.com/news/lorimer-appointed-coo monthly 0.5 2026-03-12 https://www.4basebio.com/news/christine-wolosin-cco monthly 0.5 2026-03-19 https://www.4basebio.com/news/amy-walker-appointed-ceo monthly 0.5 2026-03-02 https://www.4basebio.com/news/4basebio-presents-at-biotechshowcase2026 monthly 0.5 2026-01-26 https://www.4basebio.com/news/4basebio-opdna-utilised-in-phase2-3-us-clinical-trial monthly 0.5 2025-10-27 https://www.4basebio.com/news/4basebio-synthetic-dna-powers-tier-1-pharma-ind-filing-for-mrna-vaccine monthly 0.5 2025-08-12 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/dea02bb2-8593-4805-9198-53fc01e31d19/Heikki.jpg News - 4basebio synthetic DNA powers tier 1 pharma IND filing for mRNA vaccine Dr. Heikki Lanckriet, 4basebio CEO, commented: “We are delighted to have supported this tier 1 pharma in their recent IND filing, which represents another major regulatory milestone for 4basebio and a clear signal of a growing industry adoption of synthetic DNA” He adds “Following closely on from the recent GMP certification of our manufacturing facility, we see increasing commercial momentum as a growing number of client programs advance into the clinic.” https://www.4basebio.com/news/4basebio-strengthens-board-with-strategic-appointment-of-biopharma-leader-dr-manja-boerman monthly 0.5 2026-03-19 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/5f981599-5339-4fd1-bef6-c338db417e28/Manja.jpg News - 4basebio strengthens board with strategic appointment of biopharma leader Dr. Manja Boerman - “4basebio is uniquely positioned to address critical bottlenecks in genetic medicine manufacturing.” I’m excited to support the team as they build a scalable, globally relevant offering that enables innovation across the next generation of therapies.” Dr. Manja Boerman https://www.4basebio.com/news/influenza-research-consortium-announces-12-million-c22-million-in-funding-for-the-development-of-a-novel-broad-spectrum-vaccine monthly 0.5 2026-03-19 https://www.4basebio.com/news/4basebio-announces-the-supply-of-its-opdna-dna-products-into-tier-1-pharma-clients-vaccine-program-tc65p monthly 0.5 2025-07-01 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/dea02bb2-8593-4805-9198-53fc01e31d19/Heikki.jpg News - 4basebio introduces new branding to reflect next phase of growth enabling development of advanced genetic therapies “This brand refresh marks an exciting milestone for 4basebio. As we continue to scale our operations and deepen our work with partners across RNA, cell and gene therapy, and vaccine development, we wanted our identity to reflect the sophistication and innovation that define our approach. Our new website and branding communicate not just who we are, but where we’re going.” Heikki Lanckriet, CEO of 4basebio. https://www.4basebio.com/news/4basebio-receives-mhra-gmp-licence-for-manufacture-and-supply-of-synthetic-dna monthly 0.5 2025-09-24 https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/dea02bb2-8593-4805-9198-53fc01e31d19/Heikki.jpg News - 4basebio receives MHRA GMP licence for manufacture and supply of synthetic DNA - Heikki Lanckriet, CEO, 4basebio, commented: “Our long-term vision is to become a leading player in the DNA space. This milestone highlights our commitment to supporting the development of cutting-edge therapies by providing GMP-grade synthetic DNA for clinical trials. It enables us to support our clients along their entire journey from discovery and research phases into both pre-clinical and clinical stages and in due course into commercial supply. This achievement underscores the hard work and innovation of our team and sets the stage for the next phase of growth of the Company.” https://images.squarespace-cdn.com/content/v1/6800cf81ffa29d1745938e9e/f79cfa95-9e07-4b7a-ae2b-77840185d38e/Amy.jpg News - 4basebio receives MHRA GMP licence for manufacture and supply of synthetic DNA - Amy Walker, COO, 4basebio, explained: ‘‘Our platform is faster, more efficient, and offers higher performance products with a better safety profile compared with traditional plasmid DNA and other synthetic DNA products. We are able to offer our clients a rapid and scalable solution for their clinical trials and future product commercialisation.” https://www.4basebio.com/news/4basebio-plc-announces-400-million-equity-issuance-and-294-million-secondary-sale monthly 0.5 2026-03-19 https://www.4basebio.com/news/4basebio-announces-the-supply-of-its-opdna-dna-products-into-tier-1-pharma-clients-vaccine-program monthly 0.5 2025-07-01 https://www.4basebio.com/news/4basebio-announces-key-milestone-with-its-client-progressing-into-phase-i-clinical-trials-of-an-mrna-vaccine-manufactured-from-4basebios-opdna monthly 0.5 2026-03-19 https://www.4basebio.com/news/4basebio-awarded-tender-to-deliver-research-and-gmp-grade-synthetic-dna-in-cpis-tender-process-for-supplying-its-rna-centre-of-excellence monthly 0.5 2026-03-19 https://www.4basebio.com/news/4basebio-receives-grant-to-advance-its-synthetic-dna-platform-and-hermes-nanoparticle-platform-for-the-development-of-thermostable-nucleic-acid-vaccines monthly 0.5 2026-03-19 https://www.4basebio.com/news/4basebio-and-neomatrix-announce-clinical-material-supply-agreement-to-develop-personalised-cancer-therapy-utilising-4basebios-proprietary-hpdna monthly 0.5 2026-03-19 https://www.4basebio.com/news/final-results-notice-of-agm-and-related-party-transaction monthly 0.5 2025-06-10 https://www.4basebio.com/news/signing-of-new-lease-and-expansion-of-manufacturing-capacity monthly 0.5 2026-03-19 https://www.4basebio.com/news/research-collaboration-for-treatment-of-neurofibromatosis-type-1 monthly 0.5 2025-06-16 https://www.4basebio.com/news/final-results-and-notice-of-agm monthly 0.5 2025-06-16 https://www.4basebio.com/news/joint-development-agreement-with-heqet-therapeutics-for-development-of-a-non-viral-vector-therapy-for-cardiac-regeneration monthly 0.5 2025-06-11 https://www.4basebio.com/news/rapidly-produced-customisable-synthetic-dna monthly 0.5 2025-06-11 https://www.4basebio.com/news/dna-manufacturing-update monthly 0.5 2026-03-19 https://www.4basebio.com/news/strategic-research-collaboration-evaluating-linear-dna-for-mrna-production monthly 0.5 2026-03-19 https://www.4basebio.com/news/joint-development-agreement-with-leucid-biofor-novel-car-t-cell-production-methods monthly 0.5 2026-03-19 https://www.4basebio.com/news/development-of-gmp-manufacturing-capacity monthly 0.5 2025-06-16 https://www.4basebio.com/news/result-of-annual-general-meeting monthly 0.5 2025-06-11 https://www.4basebio.com/news/patent-application-application-filed-for-protected-linearised-synthetic-dna monthly 0.5 2026-03-19 https://www.4basebio.com/news/notice-of-annual-general-meeting monthly 0.5 2025-06-11 https://www.4basebio.com/news/evaluation-licence-for-muscular-dystrophy-vector monthly 0.5 2025-06-11 https://www.4basebio.com/case-studies daily 0.75 2026-03-09 https://www.4basebio.com/case-studies/developing-personalized-cancer-vaccines-with-synthetic-dna-neomatrixs-race-against-time monthly 0.5 2025-06-24 https://www.4basebio.com/case-studies/helixnano-accelerates-mrna-vaccine-development-with-synthetic-dna-from-4basebio monthly 0.5 2025-06-24 https://www.4basebio.com/case-studies/category/Case+study monthly 0.5 https://www.4basebio.com/videos-webinars daily 0.75 2026-03-09 https://www.4basebio.com/videos-webinars/switch-to-cell-free-dna-webinar monthly 0.5 2026-02-10 https://www.4basebio.com/videos-webinars/opdna-a-novel-synthetic-dna-starting-material-for-the-production-of-mrna-therapies-and-vaccines monthly 0.5 2026-02-05 https://www.4basebio.com/videos-webinars/4basebio-company-introduction monthly 0.5 2026-02-05 https://www.4basebio.com/videos-webinars/hpdna-for-aav-production monthly 0.5 2026-02-10 https://www.4basebio.com/videos-webinars/opdna-for-mrna-production monthly 0.5 2026-02-05 https://www.4basebio.com/videos-webinars/category/Video monthly 0.5 https://www.4basebio.com/videos-webinars/category/Webinar monthly 0.5 https://www.4basebio.com/content-hub daily 0.75 2026-02-23 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