DNA manufacturing
Redefined
We are redefining next generation genetic medicine with synthetic DNA amplification technology
4
INDs/CTAs Supported
>500
Different constructs synthesized
3
Grades: RUO, HQ & GMP
>125
Customers served
WHY SYNTHETIC
Eliminate the limitations of plasmid with synthetic DNA
Our synthetic, cell-free DNA amplification technology eases manufacturing burdens, reduces costs, and eliminates risk, supporting each development stage, from preclinical to commercialization.
4x faster
Cell-free amplification removes fermentation, cell banking and lengthy purification from the critical path. What takes months with plasmid takes weeks with synthetic DNA.
From discovery to clinic
Three quality grades: RUO, HQ and GMP. Scalable synthetic DNA manufacturing to support your programme from early research through clinical development.
Enhanced safety
Free from bacterial backbones and antibiotic-resistance genes, with no bacterial-derived endotoxin contamination risk.
Purity
Enzymatically amplified and sequence-verified DNA, manufactured to deliver exceptional purity for demanding therapeutic applications.
Efficient by design
Application-specific constructs achieve more with less input material, improving yields and simplifying workflows.
APPLICATIONS
High-Quality Synthetic DNA for Your Next-Gen Medicine Needs
With state-of-the-art, application-specific synthetic DNA solutions, 4basebio is a leading DNA company supporting the diverse needs of next-generation therapies. With synthetic DNA, you’ll reach proof-of-concept and subsequent clinical milestones faster and more efficiently while ensuring the highest safety and quality standards for your genetic medicines.
mRNA vaccines & therapeutics
Improve your mRNA yields and simplify production workflows.
Viral vectors
Mitigate packing of exogenous sequences, while achieving equivalent viral titers using less DNA input material.
Gene editing
Increase gene editing efficiency with ssDNA templates across a wide range of gene editing applications.
CUSTOM MANUFACTURING
Manufacturing that moves at the speed of innovation
4basebio delivers high-quality synthetic DNA through proprietary cell-free amplification technology, eliminating the bottlenecks of traditional plasmid DNA production. We remove long lead times, host-cell contaminants, and antibiotic resistance genes, giving you a faster, cleaner path from research to clinic.
Our team combines deep molecular biology expertise with GMP-grade manufacturing capabilities. Whether you need research-grade material or full-scale clinical production, we provide the quality, consistency, and regulatory rigor to accelerate your next-generation therapy.
Latest news from 4basebio
CONTENT HUB
Technology
Find out more about our enzymatic manufacturing process and the benefits of synthetic DNA
Synthetic DNA
Discover our RUO, HQ and GMP-grade synthetic DNA, designed for every stage from discovery to commercial production.