APPLICATIONS
We understand the challenges that come with using plasmid DNA, that is why our synthetic DNA constructs are application-specific. Whether you are advancing gene and cell therapies, developing mRNA vaccines, driving genome editing, or creating DNA vaccines, our synthetic DNA delivers a safer, flexible, and more efficient solution
Application-specific synthetic DNA solutions
Applications
Produce equivalent titers with less DNA mass and no risk of reverse packaging
mRNA vaccines & therapies
Increase mRNA yields with less DNA input compared to plasmid DNA
Gene editing
Achieve increased gene editing efficiency compared to plasmid DNA
Achieve significant dose reduction compared to plasmid DNA
DNA vaccines
Customizable, scalable delivery platform compatible with 4basebio payloads
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Fast manufacturing and downstream process
Scalable process from mg to multigram batches
No master cell bank or yield optimization needed
No risk of batch failure
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No bacterial sequences
No antibiotic resistance genes
No bacterial contaminants such as endotoxins, host protein, and genomic DNA
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Suitable for complex sequences (ITRs/LTRs and long continuous poly-A tails)
Suitable for sequences with high GC content
Suitable for long sequences (up to ~20kb)
Suitable for sequences toxic to bacteria
More copies per gram
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Sequence and size independent
Defined, controlled, and scalable process
Simple and consistent downstream purification process
High fidelity DNA polymerase
Technology
Find out more about our enzymatic manufacturing process and the benefits of synthetic DNA.
Custom manufacturing
Discover our RUO, HQ, and GMP-grade synthetic DNA, designed for every stage from discovery to commercial production