Viral vectors
Choice of DNA template is critical to producing high-quality viral vectors. hpDNA is a suitable replacement for plasmid DNA for the production of rAAV via transient transfection in a producer cell line.
Free from a bacterial backbone, synthetic DNA eliminates the risk of encapsidating these unwanted sequences, ensuring safer and more efficient viral vector production. With hpDNA, you can achieve equivalent titers with less DNA input, helping improve your workflow efficiency.
hpDNA
hpDNA is a double-stranded linear DNA, covalently closed with single-strand hairpins at the 5’ and 3’ ends
Benefits of using hpDNA
No risk of packaging bacterial backbone as it is not present in the original template
Equivalent titers with less DNA mass required
Reduction in lead times
Enhanced safety profile and regulatory compliance
What we offer
Flexible solutions for rAAV
Production of custom hpDNA templates
Off-the-shelf rep-cap, (serotype 2, 5, 8, 9) Adhelper, and reporter genome rAAV constructs
Accelerated DNA manufacturing compared to plasmid DNA
Available in RUO, HQ and GMP grade
Technology
Find out more about our enzymatic manufacturing process and the benefits of synthetic DNA.
Manufacturing
Discover our RUO, HQ, and GMP-grade synthetic DNA, designed for every stage from discovery to commercial production