Eliminate the limitations of plasmid DNA and accelerate your project with cell-free synthetic DNA. Our integrated CDMO services remove bottlenecks and provide high-quality material, giving your team the flexibility to scale projects from early-stage research to regulatory-ready clinical applications.
The next generation of genetic medicine starts here
Our custom cell-free manufacturing services
As experts in cell-free DNA amplification, we specialize in manufacturing high-quality synthetic DNA as an alternative to plasmid DNA (pDNA). Our cell-free approach addresses the main challenges of pDNA, such as long lead times, high costs, host-cell contaminants and antibiotic resistance genes. 4basebio’s DNA enables a smoother path from research to clinic, giving you the confidence and agility to accelerate your next-generation therapy.
Our teams bring together expertise in molecular biology, process development, and a deep understanding of GMP-compliant process requirements. With a thorough understanding of regulatory standards, we ensure every customer’s manufacturing program is designed for quality, consistency, and scalability. Our DNA CDMO capabilities span from early-stage, research-grade production through to full-scale GMP manufacturing, enabling us to support you seamlessly at every step of your clinical journey.
A focus on DNA amplification and drug substance manufacturing
Building on our DNA expertise, 4basebio also manufactures RNA using our opDNA® and provides LNP formulation services, enabling a continuous link between DNA template production, RNA synthesis, and encapsulation. This capability ensures precise control over each stage of development and delivers high-quality materials to suit your project.
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Available in RUO, HQ, GMP-grade manufacturing
opDNA® for mRNA vaccines and therapeutics
hpDNA for viral vector production and DNA vaccines
ssDNA for gene editing applications
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Comprehensive manufacturing services providing high-quality RNA derived from cell-free synthetic DNA.
mRNA
saRNA
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Hermes nanoparticle platform ensures efficient delivery of DNA and RNA, enabling safe and effective genetic therapies across a range of applications.
Ready to make the switch? Request a quote today
Our facilities
Single GMP manufacturing campus to support your needs
4basebio’s GMP-licensed manufacturing facility, located at the Buckingway Business Park near Cambridge, UK, provides the foundation for producing our high-quality synthetic DNA and RNA materials. Purpose-built to meet the rigorous standards of next-generation therapies, our facility integrates advanced processes, robust quality control systems and scalable manufacturing capacity.
Our GMP certification reflects more than regulatory compliance, it represents our commitment to quality, reliability, and partnership. By operating to these exact standards, we enable our customers to accelerate development timelines, reduce regulatory risk, and progress smoothly from research to clinical manufacturing.
Our commitment to partners extends far beyond our UK facilities. With dedicated support teams worldwide, we provide expertise in process development, regulatory compliance, and project management at every stage of development. By combining real-time collaboration with deep technical knowledge, we ensure seamless scale-up, consistent quality, and efficient progression from research to clinical and commercial supply.
Dedicated enzyme manufacturing facility
4basebio operates a specialized facility based in Madrid to produce enzymes that are integral to our DNA manufacturing process. By producing these enzymes in-house, we maintain full control over quality and consistency, ensuring that every batch meets our high standards. This capability not only guarantees reliable performance in downstream manufacturing but also mitigates supply chain risks, providing our partners with uninterrupted access to critical starting materials.
Enzyme Manufacturing Facility: In addition to our Cambridge sites, we operate an enzyme manufacturing facility in Madrid, Spain, where we produce the enzymes used in our synthetic, cell-free manufacturing process.
Headquarters and R&D facilities: Located near Cambridge, our Over site hosts R&D teams and key corporate functions in a peaceful countryside setting with close ties to a world-renowned scientific community.
GMP Manufacturing Facility: Our GMP facility at Buckingway Business Park in Swavesey near Cambridge is equipped with modern cleanrooms and advanced systems to support high-quality, reliable manufacturing.
Applications
Find out more about our enzymatic manufacturing process and the benefits of synthetic DNA.
Technology
Find out more about our enzymatic manufacturing process and the benefits of synthetic DNA