Gene Editing
Accelerate safer HDR-based therapeutics with enzymatic ssDNA
Overcome the limitations of traditional chemical synthesis and enable a faster, cleaner path to next-generation medicines.
The future of knock-in applications requires a better template
For therapeutic developers working on HDR (Homology-Directed Repair) knock-in applications, template quality is the bottleneck. Traditional chemical synthesis is often plagued by limited scale, toxic byproducts, and purity issues that stall progress.
We provide a specialized solution for both in vivo and ex vivo therapies. By utilizing a proprietary enzymatic process, we deliver unparalleled product quality without the risk of antibiotic gene insertion. It’s the stability and safety your therapeutics demand, engineered for the scale you need.
Engineered for unrivaled performance
Purity & Safety
By moving away from traditional chemical synthesis, our templates eliminate toxicity and immunogenicity, ensuring safer therapeutic development.
Highly Scalable
Do not let capacity limit your innovation. Optimized for efficient production of large, consistent ssDNA batches of up to 50mg at RUO grade.
Maximum Stability
Our ssDNA templates feature protected ends that shield the sequence from degradation, maximizing your HDR efficiency in the target cell.
Long Templates
Our platform allows you to successfully execute complex knock-ins with a massive template capacity of up to 10,000 nucleotides
Let our DNA experts customize a solution just for you.
Advancing key therapeutic modalities
Whether you are engineering cells outside the body or developing direct-to-patient treatments, your template must perform flawlessly. Our enzymatic ssDNA is purposefully designed to meet the rigorous demands of advanced gene editing, overcoming the unique manufacturing and performance constraints of traditional chemical synthesis.
Ex Vivo Therapies: Engineer cells with confidence. Our high-purity templates reduce cellular toxicity and immune responses, ensuring healthier engineered cells for adoptive cell therapies.
In Vivo Therapies: Deliver safer therapeutics directly to the patient. With no risk of antibiotic resistance gene insertion and highly stable protected ends, our ssDNA supports a cleaner path for advanced in vivo gene editing.
Complex HDR Knock-Ins: Leverage the high-capacity, 10,000-nucleotide template to successfully execute large, complex gene insertions that were previously hindered by the length limits of traditional chemical synthesis
Ready to clear the contraints for your ssDNA process?
Partner with us to integrate high-capacity, enzymatically produced ssDNA into your next breakthrough.
Technology
Find out more about our enzymatic manufacturing process and the benefits of synthetic DNA.
Custom Manufacturing
Discover our RUO, HQ, and GMP-grade synthetic DNA, designed for every stage, from discovery to commercial production