PERSONALIZED CANCER VACCINES & THERAPIES
Built for the demands of personalized oncology, our cell-free DNA platform removes the barriers of traditional plasmid DNA manufacturing. Achieve greater speed, purity, and flexibility without compromising quality.
Custom synthetic DNA solutions for personalized cancer vaccines
High-purity synthetic DNA for faster “batch-of-one” therapies
In the race to deliver personalized oncology, traditional DNA manufacturing is the bottleneck. Traditional plasmid manufacturing is slow and carries the risk of bacterial contamination. Our proprietary enzymatic platform eliminates these hurdles, providing a streamlined path from design to delivery. 4basebio provides a high-purity, cell-free alternative to legacy processes, delivering the consistency and timelines your therapeutics demand. Our platform is particularly well suited to the development of personalized mRNA cancer vaccines, where speed, purity, and manufacturing flexibility are critical.
Following upfront process development and pre-manufacturing steps, 4basebio can deliver Personalized Cancer Vaccine (PCV) batch manufacturing in as little as 2–4 weeks*, enabling our partners to meet demanding clinical timelines and helping ensure patient-specific treatments reach those who need them most.
When every patient is unique, your DNA manufacturing should be too.
*This timeline can be achieved with prior process development steps over a 12–14 week period
Explore our cell-free DNA for Personalized Cancer Vaccine applications
Optimized performance for next-gen oncology
High-fidelity, linear DNA templates feature unique hairpin structures and protected 3’ and 5’ ends, offering a cleaner, safer, and more efficient alternative to legacy plasmids.
THE CELL-FREE ADVANTAGE
Accelerated 2-4 week turnaround*
Rapid synthetic DNA manufacturing helps keep personalized cancer vaccine programs on schedule.
High-purity synthetic DNA
Cell-free production eliminates bacterial-derived impurities, providing a clean DNA template for mRNA synthesis.
Designed for personalized therapies
Flexible manufacturing supports small batch requirements of individualized, batch-of-one cancer vaccines.
Enhanced efficiency
Homogeneous templated PolyA tails of up to 120bp+, combined with direct-to-IVT use without linearization support efficient mRNA production.
From tumor sequencing to treatment
Accelerating the journey from design to delivery with high-purity synthetic DNA
Every step in the personalized cancer vaccine journey is time critical. Once tumor-specific neoantigens have been identified, rapid and reliable DNA manufacturing is essential to keep development moving towards patient treatment.
4basebio’s unique DNA manufacturing workflow
To enable quick turnaround times for personalized cancer vaccines, 4basebio has developed a specialised workflow designed for efficient, patient-specific DNA manufacturing.
Want to know more about how 4basebio manufacturing is delivered?
Explore the complete process, from pre-manufacturing preparation through cell-free production and release, in our PCV brochure.
A partner you can trust
From early development through clinical and commercial manufacturing, our experienced team works with you to develop a DNA manufacturing solution tailored to your PCV program.
Technology
Find out more about our enzymatic manufacturing process and the benefits of synthetic DNA.
Custom Manufacturing
Discover our RUO, HQ, and GMP-grade synthetic DNA, designed for every stage, from discovery to commercial production