Be a part of the 4basebio team

We are expanding our MSAT team at our site just north of Cambridge, UK to facilitate the purification of synthetic DNA products for use in AAV, IVT mRNA processes and other therapeutic areas. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals. 

The role will support the development, optimisation and validation of new products within the company.

In addition, there will be opportunity for the candidate to interact with multi-disciplinary teams within the Research department and expand their laboratory skill set.

Responsibilities:

• Work to develop and optimise new and existing DNA products

• Perform screening and optimisation experiments using 4basebio DNA

• Generate documentation, such as reports/experimental write-ups, that support the development & optimisation of production processes

• Support troubleshooting activities and assist with continuous improvement initiatives

• Work to develop and optimise processes within MSAT, to ensure successful manufacture of DNA products

• Perform analysis of experimental data

• Work collaboratively to support the R&D and manufacturing functions of the Company

• Record experimental methods and results to a high standard and in-line with company guidelines

• Present commercial data to a high standard in internal meetings

• Keep up to date with relevant scientific and technical developments 

• Attend and participate in relevant meetings, training, and development sessions

• Use, maintain and respect company equipment in accordance with the company’s SOPs and health & safety guidelines

• Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested

• Be prepared to travel to other 4basebio sites

Person Specification:

• BSc in biological sciences, or a related discipline

• Experience of experimental planning, experimental design and data analysis is required

• Extensive practical experience of techniques including gel electrophoresis, DNA & RNA handling and DNA quantification is required

• Strong knowledge and practical experience in molecular biology techniques

• Highly confident in pipetting techniques

• Excellent team working and communication skills

• Excellent record keeping skills

We are expanding our R&D teams at our site in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process including RNA synthesis and development of nanoparticle vectors for nucleic acid delivery. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.

Job purpose:

To contribute to new client or collaborator on RNA synthesis and related R&D projects. Contribute to development of novel RNA based products offering solutions in therapeutic and applied space.

Responsibilities:

• Work as part of the RNA team, to be able of generating consistent and valuable data for collaborative and client based projects

• Perform screening and optimisation experiments using 4basebio DNA for in vitro transcription (IVT) for various applications (mRNA, saRNA and circRNA)

• Perform RNA purification and analytics on mRNA and saRNA produced with IVT

• Nanopore based direct RNA sequencing of IVT products and its analysis

• Execute and deliver projects to a high standard and in accordance with project plans

• Analyse and interpret experimental data; identify and solve experimental problems

• Work collaboratively and support the R&D functions of the company

• Record experimental methods and results to a high standard and in-line with company guidelines

• Attend and participate in relevant meetings, training, and development sessions

• Keep up to date with relevant scientific and technical developments

• Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested

• Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines

Person Specification:

• MSc with relevant experience or PhD in biological sciences, molecular biology, or in life sciences

• Hands-on experience working in molecular biology preferably RNA related projects in R&D labs

• Knowledge and practical experience in molecular biology with focus on RNA based techniques

• Experience in analytical techniques including agarose and polyacrylamide gel electrophoresis, nanopore RNA sequencing, capillary electrophoresis, ELISA, qPCR, flow cytometry, dot blot

• Excellent record keeping skills

• Ability to test and troubleshoot new assays and techniques

• Excellent team working and communication skills

This role description may be subject to amendment to take account of changing circumstances but such amendments will only be made following consultation between the post-holder and line manager/head of department.