MANUFACTURING

Designed to meet your needs from early-stage research to GMP-grade production

Accelerate your path through clinic and receive GMP-grade custom synthetic DNA, from sequence to final product in as little as 8 weeks. 4basebio’s state-of-the-art MHRA approved GMP manufacturing facility and expert team, help you move swiftly from early-stage research to clinical trials and commercialization with compliance and enhanced safety

4basebio timeline

Traditional pDNA timeline

4basebio timeline

Traditional pDNA timeline

Product grades to suit your needs

Our enzymatic DNA manufacturing platform delivers highly pure, customizable DNA constructs
with speed, scalability, and regulatory confidence. Whether you are optimizing a therapeutic candidate or preparing for clinical manufacturing, we support your journey every step of the way.

Three levels of manufacturing ranging from 1 mg to 10 g ensure that you have the correct batch size to suit your scale from discovery through to late-phase clinical trials.

Product specifications

4basebio provides high-quality synthetic DNA to meet your exact needs. Each DNA grade comes with clearly defined specifications and is backed by comprehensive analytics, to ensure high quality, purity, and regulatory compliance you can rely on

RUO batch sizes start at 1 mg with HQ and GMP ranging from 50 mg to 10 g

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Specification RUO HQ GMP
Product Formulation Check Check Check
DNA characterisation Check Check Check
Certification Certificate of Analysis Check Check Check
Statement of Origin Check Check
Quality Batch manufacturing record Check Check
Qualified testing & production methods Check
QMS controlled Check
Environment Grade C cleanroom Check Check
Dedicated suite during manufacture Check Check
Materials GMP certified raw materials Check
Compliance EU, GMP, Volume 4, Part II Check
Mobile Table Fix
Specification RUO HQ GM
Product
Formulation Check Check Check
DNA characterisation Check Check Check
Certification
Certificate of analysis Check Check Check
Statement of origin Check Check
Quality
Batch manufacturing record Check Check
Qualified testing & production methods Check
QMS controlled Check
Environment
Grade C cleanroom Check Check
Dedicated suite during manufacture Check Check
Materials
GMP certified raw materials Check
Compliance
EU, GMP, Volume 4, Part II Check

Technology

Find out more about our enzymatic manufacturing process and the benefits of synthetic DNA.

Applications

See how synthetic DNA is driving innovation in mRNA vaccines & therapeutics, gene editing, cell & gene therapies and DNA vaccines